深圳市正常體質(zhì)量指數(shù)成人骨密度和峰值骨密度的調(diào)查
作者:吳伏娜,鐘紫茹,韓全水,林小嵐【關(guān)鍵詞】 骨密度
Investigation of bone density and peak bone density of healthy adult residents with normal body mass index in Shenzhen
【Abstract】 AIM: To investigate the bone density and peak bone density (PBD) in healthy residents with normal body mass index in Shenzhen City for the prevention of osteoporosis in Shenzhen. METHODS: Bone mineral density of 677 healthy residents, who were aged over 20 and has lived in Shenzhen for more than 10 years, was measured by dual-energy X-ray absorption-metry (DEXA). The subjects were divided into 14 age groups with five years in each group. RESULTS: The PBD of lumbar vertebral and femoral neck and wards triangle was observed in 25-29 male group and in 35-39 female group and the PBD of neck and wards triangle was observed in female 40-44 group. The highest bone mass density was found in 80-84 male group. The bone mass density dropped rapidly from 45 years on in females. CONCLUSION: Female PBD appears later than male PBD, just before menopause. The PBD in female is drops rapidly from 45 years on, while that in males drops from the age of 65 or 70. Prevention of osteoporosis should starts with the elevation of PBD in adolescents.
【Keywords】 bone density; peak bone density; body mass index
【摘要】 目的: 調(diào)查深圳市正常體質(zhì)量指數(shù)人群骨密度和峰值骨密度(PBD),以期為深圳地區(qū)骨質(zhì)疏松癥防治工作提供理論依據(jù). 方法: 近5 a體檢的健康成年677名,年齡20以上,男女性均以5歲一個年齡段分為14組;雙能X光骨密度儀測量骨密度. 結(jié)果: 男性各部位PBD值出現(xiàn)在25~歲,女性各腰椎PBD值出現(xiàn)在35~歲,髖部PBD值出現(xiàn)在40~歲. 在80~歲年齡段,男性腰椎骨密度出現(xiàn)高于其PBD的另一個峰值,女性骨密度自45~歲年齡段后隨年齡逐年下降. 結(jié)論: 女性PBD形成晚于男性而接近絕經(jīng)期;其骨密度自45歲年齡段迅速減低, 而男性則發(fā)生在65歲年齡段;骨質(zhì)疏松的預(yù)防應(yīng)從青少年時期提高PBD開始.
【關(guān)鍵詞】 骨密度;峰值骨密度;體重指數(shù)
0引言
峰值骨密度(peak bone desity, PBD)是人骨質(zhì)生長期獲得的最大骨礦物質(zhì)含量,其數(shù)值可預(yù)測中老年時期骨質(zhì)丟失程度以及骨質(zhì)疏松癥的發(fā)病率,已成為骨質(zhì)疏松研究的熱點(diǎn)之一. PBD受遺傳和環(huán)境因素的影響,在環(huán)境因素中,體質(zhì)量是重要因素之一. 我們選取深圳市正常體質(zhì)量指數(shù)人群,采用雙能X光骨密度儀檢測骨密度,排除體質(zhì)量因素對骨密度的影響,得出深圳地區(qū)PBD值,從而為深圳地區(qū)骨質(zhì)疏松癥的防治工作提供理論依據(jù).
1對象和方法
1.1對象
200005/200412我院進(jìn)行體檢的正常體質(zhì)量健康成年人677例,職業(yè)為干部、商人、公司職員、醫(yī)護(hù)人員、工人、無業(yè)人員等,體質(zhì)量指數(shù)在18~24 kg/m2,年齡20歲以上,除外內(nèi)分泌、慢性阻塞性肺部疾患、風(fēng)濕性疾病及進(jìn)行骨質(zhì)疏松治療者,居住深圳10 a以上.
1.2方法
按每5歲一個年齡段分組. 由專人用Challenger“99”雙能X光骨密度測量儀檢測L3,L24及髖部Neck,Wards部位的骨密度. 每次檢測前儀器均進(jìn)行自檢,儀器重復(fù)測定的變異系數(shù)為1.3%.
統(tǒng)計學(xué)處理: 使用SPSS11.0統(tǒng)計軟件對數(shù)據(jù)進(jìn)行統(tǒng)計學(xué)處理. 各年齡組的總體差異檢驗采用方差分析,各年齡組與PBD組比較采用Dunnettt檢驗,P
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